Available online

  • Articles 3759
  • Volumes 11
  • Issues 120

UDK: 547.757

2016. - V. 30. - N 1(170). - P. 44-45

Nikolay Vyacheslavovich Osipenko, Sergey Anatolyevich Maklakov,

SYNTHESIS OF 5-ACETAMINO-2-METHYLINDOLE-3-ACETIC ACID

In order to obtain an analog of anti-inflammatory drug indomethacin perfected chain of syntheses. Examing the methods for 4-nitroacetanilide by nitration of acetanilide and acetylation of 4-nitroaniline. Reduction of 4-nitroacetanilide is received 4-aminoacetanilide. With diazotization and subsequent reduction it synthesized hexachlorostannate 4-acetaminophenylhidrazine. His interaction with the ethyl levulinic acid obtained 5-acetamino-5-methylindole-3-acetic acid.

Get PDF

First page of the article:

СИНТЕЗ 5-АЦЕТАМИНО-2-МЕТИЛИНДОЛИЛ-3-УКСУСНОЙ КИСЛОТЫ

References

  1. M

Keywords

4-nitroacetanilide   acetylation   diazotation   Fischer reaction   indometacin   nitration   reduction   ацетилирование   восстановление   диазотирование   индометацин   нитрование   п-нитроацетанилид   реакция Фишера  


Journal indexing

  • Elibrary.ru
  • Винити

Our friends

  • Фонд "Научная перспектива"
  • Минобрнауки
  • РХО им. Д.И. Менделеева