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UDK: 615.453

2014. - V. 28. - N 1(150). - P. 53-56

Daria Dmitrievna Lovskaya, Artem Evgenievich Lebedev, Natalia Vasilievna Menshutina,

INCREASING OF PHARMAKOKINETIC PROPERTIES OF ACTIVE SUBSTANCES BY IMPREGNATION INTO THE AEROGEL MATRICE

It was conducted a number of experiments of ibuprofen adsorption into the aerogel support matrices based on inorganic (silica) and organic (starch, sodium alginate) materials in the supercritical high-pressure reactor. The dissolution kinetic curves of composites “aerogel-ibuprofen” were obtained and it was established the solubility increasing of obtained composites more than 1,5 times. It allows using aerogel-based matrices for the increasing of pharmacokinetic properties of active substances.

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Keywords

aerogel   drug delivery systems   supercritical adsorption   аэрогель   сверхкритическая адсорбция   системы доставки лекарств